Dr Niyaz Ahmed, Head of the Laboratory/Chairman of the Department

NA_OBM (2)Niyaz Ahmed (Researcher ID D-2589-2010) is a leading microbiologist, veterinarian, science blogger,  and an Open Access advocate based in Hyderabad, India.  Fellow of the  Royal Society of Chemistry, Royal Society of Biology and the National Academy of Sciences India, as well as the founding Editor -in-Chief of Gut  Pathogens journal, Dr Ahmed is also the recipient of the ‘National  Bioscience Award‘  of India.

Ahmed graduated in Veterinary Medicine in 1995 (Nagpur) and obtained  further degrees in Animal Biotechnology (MS) (NDRI, Karnal) and  Infectious Diseases (PhD) (Manipal University).

In December 2008, he  joined the University of Hyderabad as a member of the Faculty and presently serving as Chairman of the Department of Biotechnology and Bioinformatics. Ahmed is also affiliated with the University of Malaya, Kuala Lumpur, Malaysia as a Visiting Professor of Molecular Biosciences at the Institute of Biological Sciences. He also serves as Adjunct Professor of the Academy of Scientific and Innovative Research, New Delhi. Dr Ahmed is a Corresponding Fellow of the European Helicobacter and Microbiota Study Group.

Ahmed has founding and pioneering contributions entailing Molecular Epidemiology of bacterial pathogens in India. His research work is primarily directed at gaining novel insights in to the evolution and acquisition of virulence through largescale comparative genomics, bioinformatics, cellular microbiology and theoretical biology of pathogenic microorganisms. His group has extensive experience in descriptive studies, such as those that identify a new genome sequence of a gut pathogen or microbe or a series of related pathogens (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution). Ahmed  made seminal contributions to host adaptation dynamics of bacterial pathogens (Ahmed et al., 2008, Nature Reviews Microbiol.), and also in unraveling the population genetic structure and virulence mechanisms of major human pathogens: H. pylori, M. tuberculosis, E. coli and S. enterica. His contributions strengthened molecular basis of survival of pathogens in single patients and in host communities with varied genetic backgrounds (Kumar/Ahmed, 2015 Nucleic Acids Res; Baddam/Ahmed 2014, Scientific Reports). Ahmed authored 125 publications with 3500 citations (H-index 34). In 2015, out of a total of 115 citable articles of Dr Ahmed: 7.8% were cited in Nature journals, 6.9% were cited in PNAS USA, 3.4% were cited in Lancet journals, 1.7% were cited in New England Journal of Medicine.

Niyaz Ahmed served as Section Editor (Genomics and Microbiology) of PLoS ONE (from August 2008 to September 2013), published by the Public Library of Science (PLoS), USA. Currently, he is providing editorial oversight to the “PLoS ONE Prokaryotic Genome Collection”. Ahmed also serves as a member of the PLoS International Advisory Group. Ahmed is a member of the International Society for Genomic and Evolutionary Microbiology (Italy) and currently serves as its General Secretary. He is also a member of the Faculty of 1000 Biology and has been elected to the Indian National Academy of Sciences. Ahmed served as an expert evaluator/panelist for the research proposals submitted to European Commission’s Seventh Framework Program.

Niyaz Ahmed is on the Editorial Boards of the following international journals: Scientific Reports (Nature), Helicobacter (Wiley), Systems and Synthetic Biology (Elsevier), Infectious Agents and Cancer (Springer),  Microbial Genomics (SGM, UK), Journal of Health & Translational Medicine (University of Malaya Medical Centre), Emerging Microbes and Infections (Nature), PLOS ONE (PLOS journals).

Niyaz Ahmed teaches the following post graduate courses at the University of Hyderabad: Metagenomics, Biosafety & Intellectual Property, Communication Skills, Scientific Writing, Comparative Systems Modeling, Research Ethics & Biostatistics.

Important publications:

(All publications)

1: Devi S, Rajakumara E, Ahmed N. Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy. Scientific Rep. 2015, 5:15049 (Open Access)

2. Ranjan A, Shaik S, Hussain A, Nandanwar N, Semmler T, Jadhav S, Wieler LH, Ahmed N. Genomic and functional portrait of a highly virulent, CTX-M-15-producing H30-Rx subclone of Escherichia coli sequence type (ST) 131. Antimicrob Agents Chemother. 2015, 59:6087-95 (Press Report)

3: Kumar N, Mariappan V, Baddam R, Lankapalli AK, Shaik S, Goh KL, Loke MF, Perkins T, Benghezal M, Hasnain SE, Vadivelu J, Marshall BJ, Ahmed N. Comparative genomic analysis of Helicobacter pylori from Malaysia identifies three distinct lineages suggestive of differential evolution. Nucleic Acids Res. 2015 Jan;43(1):324-35 (Open Access)

4:Baddam R, Kumar N, Shaik S, Lankapalli AK, Ahmed N. Genome dynamics and evolution of Salmonella Typhi strains from the typhoid-endemic zones. Scientific Rep 2014 Dec 12;4:7457 (Open Access)

5: Hussain A, Ranjan A, Nandanwar N, Babbar A, Jadhav S, Ahmed N. Genotypic and phenotypic profiles of Escherichia coli isolates belonging to clinical sequence type 131 (ST131), clinical non-ST131, and fecal non-ST131 lineages from India. Antimicrob Agents Chemother. 2014 Dec;58(12):7240-9 (Open Access)

6: Tenguria S, Ansari SA, Khan N, Ranjan A, Devi S, Tegtmeyer N, Lind J, Backert  S, Ahmed N. Helicobacter pylori cell translocating kinase (CtkA/JHP0940) is pro-apoptotic in mouse macrophages and acts as auto-phosphorylating tyrosine kinase. Int J Med Microbiol. 2014 Nov;304(8):1066-76.

7: Rani PS, Babajan B, Tulsian NK, Begum M, Kumar A, Ahmed N. Mycobacterial Hsp65 potentially cross-reacts with autoantibodies of diabetes sera and also induces (in vitro) cytokine responses relevant to diabetes mellitus.  Mol Biosystems 2013, Nov; 9(11):2932-41.

8: Hussain A, Ewers C, Nandanwar N, Guenther S, Jadhav S, Wieler LH, Ahmed N. Multiresistant uropathogenic Escherichia coli from a region in India where urinary tract infections are endemic: genotypic and phenotypic characteristics of sequence type 131 isolates of the CTX-M-15 extended-spectrum-β-lactamase-producing lineage. Antimicrob Agents Chemother. 2012 Dec;56(12):6358-65 (Open Access)

9: Alvi A, Ansari SA, Ehtesham NZ, Rizwan M, Devi S, Sechi LA, Qureshi IA, Hasnain SE, Ahmed N. Concurrent proinflammatory and apoptotic activity of a Helicobacter pylori protein (HP986) points to its role in chronic persistence. PLoS One 2011;6(7):e22530 (Open Access)

10. Nalam K, Ahmed A, Devi SM, Francalacci P, Baig M, Sechi LA, Hartskeerl RA, Ahmed N. Genetic affinities within a large global collection of pathogenic Leptospira: implications for strain identification and molecular epidemiology. PLoS One. 2010 Aug 27;5(8):e12637 (Open Access)

11: Ahmed N, Dobrindt U, Hacker J, Hasnain SE. Genomic fluidity and pathogenic bacteria: applications in diagnostics, epidemiology and intervention. Nat Rev Microbiol. 2008 May;6(5):387-94.

12: Devi SM, Ahmed I, Francalacci P, Hussain MA, Akhter Y, Alvi A, Sechi LA, Mégraud F, Ahmed N. Ancestral European roots of Helicobacter pylori in India. BMC Genomics 2007 Jun 20;8:184 (Open Access)

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