Dr Niyaz Ahmed, Head of the Laboratory/Chairman of the Department
Niyaz Ahmed (Researcher ID D-2589-2010) is a leading Indian biologist, veterinarian, science blogger, and an Open Access advocate based in Hyderabad, India. A Fellow of the Royal Society of Chemistry (UK), Royal Society of Biology (UK) and the National Academy of Sciences India, as well as the founding Editor -in-Chief of Gut Pathogens journal, Dr Ahmed is also the recipient of the ‘National Bioscience Award‘ of India (2013) and the Chancellor’s Award of the University of Hyderabad (2015).
Dr Ahmed graduated in Veterinary Medicine in 1995 (Nagpur), and then obtained a Master’s degree in Animal Biotechnology (NDRI, Karnal) in 1997. He earned a PhD from the Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India (Manipal University), in 2008, where he had also been working as a Staff Scientist since 1998 and a Group Leader since 2002.
In December 2008, Dr Ahmed joined the University of Hyderabad, on technical resignation from CDFD, after accepting the invitation extended by the University to strengthen its newly founded Biotechnology/Bioinformatics Department. Dr Ahmed is presently serving as Chairman of the Department of Biotechnology and Bioinformatics at the School of Life Sciences. He also holds appointment as Adjunct Professor of the Academy of Scientific and Innovative Research, India. Dr Ahmed is a Corresponding Fellow of the European Helicobacter and Microbiota Study Group.
Through his productive and translational work, sustained commitment and dedication to public health microbiology in India, Ahmed made founding and pioneering contributions to the development of Molecular Epidemiology of bacterial pathogens in this country. Ahmed made seminal contributions to host-pathogen epidemiology of bacterial pathogens such as TB bacilli and Helicobacters (Ahmed et al., 2008, Nature Reviews Microbiol.), and also in unraveling the population genetic structure and virulence mechanisms of major human pathogens: H. pylori, M. tuberculosis, E. coli and S. enterica. His contributions strengthened molecular basis of survival of pathogens in single patients and in host communities with varied genetic backgrounds (Kumar/Ahmed, 2015 Nucleic Acids Res; Baddam/Ahmed 2014, Scientific Reports). Ahmed authored 125 publications with 3500 citations (H-index 34). In 2015, out of a total of 115 citable articles of Dr Ahmed: 7.8% were cited in Nature journals, 6.9% were cited in PNAS USA, 3.4% were cited in Lancet journals, 1.7% were cited in New England Journal of Medicine.
Niyaz Ahmed served as Section Editor (Genomics and Microbiology) of PLoS ONE (from August 2008 to September 2013), published by the Public Library of Science (PLoS), USA. Currently, he is providing editorial oversight to the “PLoS ONE Prokaryotic Genome Collection“. Ahmed also serves as a member of the PLoS International Advisory Group. Ahmed is a member of the International Society for Genomic and Evolutionary Microbiology (Italy) and currently serves as its General Secretary. He is also a member of the Faculty of 1000 Biology. Ahmed served as an expert evaluator/panelist for the research proposals submitted to European Commission’s Seventh Framework Program.
Niyaz Ahmed is on the Editorial Boards of the following international journals: Scientific Reports (Nature), Helicobacter (Wiley), Systems and Synthetic Biology (Elsevier), Infectious Agents and Cancer (Springer), Microbial Genomics (SGM, UK), Journal of Health & Translational Medicine (University of Malaya Medical Centre), Emerging Microbes and Infections (Nature), PLOS ONE (PLOS journals) and F1000 Research (F1000, UK).
Niyaz Ahmed teaches the following post graduate courses at the University of Hyderabad: Metagenomics, Biosafety & Intellectual Property, Communication Skills, Scientific Writing, Comparative Systems Modeling, Research Ethics & Biostatistics.
Important and noteworthy publications:
1: Shaik S, Kumar N, Lankapalli AK, Tiwari SK, Baddam R, Ahmed N. Contig-Layout-Authenticator (CLA): A Combinatorial Approach to Ordering and Scaffolding of Bacterial Contigs for Comparative Genomics and Molecular Epidemiology. PLoS One 2016, 11:e0155459 (Open Access)
2: Peddireddy V, Doddam SN, Qureshi IA, Yerra P, Ahmed N. A putative nitroreductase from the DosR regulon of Mycobacterium tuberculosis induces pro-inflammatory cytokine expression via TLR2 signaling pathway. Scientific Rep. 2016, 6:24535 (Open Access)
3: Devi S, Rajakumara E, Ahmed N. Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy. Scientific Rep. 2015, 5:15049 (Open Access)
4: Ranjan A, Shaik S, Hussain A, Nandanwar N, Semmler T, Jadhav S, Wieler LH, Ahmed N. Genomic and functional portrait of a highly virulent, CTX-M-15-producing H30-Rx subclone of Escherichia coli sequence type (ST) 131. Antimicrob Agents Chemother. 2015, 59:6087-95 (Press Report)
5: Kumar N, Mariappan V, Baddam R, Lankapalli AK, Shaik S, Goh KL, Loke MF, Perkins T, Benghezal M, Hasnain SE, Vadivelu J, Marshall BJ, Ahmed N. Comparative genomic analysis of Helicobacter pylori from Malaysia identifies three distinct lineages suggestive of differential evolution. Nucleic Acids Res. 2015 Jan;43(1):324-35 (Open Access)
6:Baddam R, Kumar N, Shaik S, Lankapalli AK, Ahmed N. Genome dynamics and evolution of Salmonella Typhi strains from the typhoid-endemic zones. Scientific Rep 2014 Dec 12;4:7457 (Open Access)
7: Hussain A, Ranjan A, Nandanwar N, Babbar A, Jadhav S, Ahmed N. Genotypic and phenotypic profiles of Escherichia coli isolates belonging to clinical sequence type 131 (ST131), clinical non-ST131, and fecal non-ST131 lineages from India. Antimicrob Agents Chemother. 2014, 58:7240-9 (Open Access)
8: Tenguria S, Ansari SA, Khan N, Ranjan A, Devi S, Tegtmeyer N, Lind J, Backert S, Ahmed N. Helicobacter pylori cell translocating kinase (CtkA/JHP0940) is pro-apoptotic in mouse macrophages and acts as auto-phosphorylating tyrosine kinase. Int J Med Microbiol. 2014, 304:1066-76.
9: Rani PS, Babajan B, Tulsian NK, Begum M, Kumar A, Ahmed N. Mycobacterial Hsp65 potentially cross-reacts with autoantibodies of diabetes sera and also induces (in vitro) cytokine responses relevant to diabetes mellitus. Mol Biosystems 2013, 9:2932-41.
10: Hussain A, Ewers C, Nandanwar N, Guenther S, Jadhav S, Wieler LH, Ahmed N. Multiresistant uropathogenic Escherichia coli from a region in India where urinary tract infections are endemic: genotypic and phenotypic characteristics of sequence type 131 isolates of the CTX-M-15 extended-spectrum-β-lactamase-producing lineage. Antimicrob Agents Chemother. 2012, 56:6358-65 (Open Access)
11: Alvi A, Ansari SA, Ehtesham NZ, Rizwan M, Devi S, Sechi LA, Qureshi IA, Hasnain SE, Ahmed N. Concurrent proinflammatory and apoptotic activity of a Helicobacter pylori protein (HP986) points to its role in chronic persistence. PLoS One 2011, 6:e22530 (Open Access)
12. Nalam K, Ahmed A, Devi SM, Francalacci P, Baig M, Sechi LA, Hartskeerl RA, Ahmed N. Genetic affinities within a large global collection of pathogenic Leptospira: implications for strain identification and molecular epidemiology. PLoS One. 2010, 5:e12637 (Open Access)
13: Ahmed N, Dobrindt U, Hacker J, Hasnain SE. Genomic fluidity and pathogenic bacteria: applications in diagnostics, epidemiology and intervention. Nat Rev Microbiol. 2008 6:387-94.